Inclusion Criteria:

1. Histological confirmation of RCC with a clear-cell component, including participants who may also have sarcomatoid features
2. Advanced (not amenable to curative surgery or radiation therapy) or metastatic (AJCC Stage IV) RCC

No prior systemic therapy for RCC with the following exception:

i) One prior adjuvant or neoadjuvant therapy for completely resectable RCC if such therapy did not include an agent that targets VEGF or VEGF receptors and if recurrence occurred at least 6 months after the last dose of adjuvant or neoadjuvant therapy

Exclusion Criteria:

1. Any active CNS metastases
2. Any active, known or suspected autoimmune disease
3. Any condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days of randomization
4. Participants who have received a live/attenuated vaccine within 30 days of first treatment

Other protocol defined inclusion/exclusion criteria could apply