Recipient Inclusion Criteria:

1. Planned recipient of a first kidney allograft from an HLA-matched, living related donor
2. Age ≥18 and ≤70 years
3. Single solid organ recipient (kidney only)
4. ABO matched with donor

Donor Inclusion Criteria:

1. HLA-matched first degree (parent, child or sibling) or second-degree (child of a sibling or half sibling) relative of the prospective recipient participant
2. Age ≥18 and ≤70 years
3. Prepared to be a living related kidney donor, and capable of undergoing G-CSF mobilization and apheresis of hematopoietic cells

Recipient Exclusion Criteria:

1. Underlying kidney disease with a high risk of disease recurrence in the transplanted kidney
2. Baseline positive donor-specific anti-HLA antibody testing
3. Is taking immunosuppressive therapy
4. Evidence of prior hepatitis B (HBV) or hepatitis C (HCV)

Donor Exclusion Criteria:

1. History of autoimmune disorders
2. History of type 1 or type 2 diabetes mellitus
3. Tests confirmed positive for human immunodeficiency virus (HIV), HBV, HCV, T. cruzi, or syphilis
4. History of infection with Zika virus